Figure 5.
Canonical interactions between the LV.D and NK.D regions within the Ras, Rho, and Ran families. The perspective is as shown in Figure4 A. Representations and coloring are as described in Figure 4. (A) Human Ras-GTP (pdb code: 1QRA). Note that a canonical tryptophan (W114Sec4) that typically forms CH-π and NH-π hydrogen bonds with P-loop main-chain atoms is displaced by a tyrosine (Y96Ras; or, within other Ras proteins, a phenylalanine), suggesting that this residue performs a Ras-specific function. (B) The Rho family human Rac1 GTPase in complex with a GTP analog (pdb code: 1MH1). (C) Canine Ran-GDP (pdb code: 1BYU).
