Table 1.
The LRA Models for NF-κB-Regulated Immune Gene Promoters
| LRA model | Model variables | Promoters with NF-κB sites from −1 to −230bp | Promoters with NF-κB sites only from −231 to −600bp | ||||
| Coeff. | S.E. | P-value | Coeff. | S.E. | P-value | ||
| Model w/o number of | Intercept | −3.45 | 0.38 | 6.1E-17 | −5.80 | 0.98 | 8.8E-09 |
| TF binding sites | NF-κB | 3.49 | 0.44 | 4.3E-14 | 4.19 | 0.95 | 1.5E-05 |
| AP1 | 0.70 | 0.47 | 0.135 | 1.35 | 0.96 | 0.160 | |
| IK | 0.87 | 0.49 | 0.074 | 1.73 | 0.81 | 0.034 | |
| IRF | 0.93 | 0.64 | 0.146 | 2.67 | 0.91 | 0.003 | |
| STAT | 1.00 | 0.44 | 0.022 | 0.70 | 0.75 | 0.355 | |
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The columns labeled Coeff. are the coefficients in the logistic regression model. S.E. is the standard error in the fit for the coefficient, and P-value is the probability of observing a coefficient this far from 0 in a fit to random data. The weight matrix score cutoff for NF-κB and AP1 sites is 0.95; that for the IK1, IK3 binding sites is 0.94; for STAT, IRF1, IRF2, and ISRE, the score cutoff is 0.91.
