Table 2.
The 11 Most Conserved Metabolic Enzymes in E. coliAccording to Their Sequence Identity to Homologs inHomo sapiens
| Accession | Description | Human homologs | Identity |
| P15344 | GMP reductase (guanosine 5′-monophosphate oxidoreductase) | Q9P2T1 AAH08021 AAH08281 P36959 | 68% 68% 65% 65% |
| P06977 | Glyceraldehyde 3-phosphate dehydrogenase A (GAPDH-A) | P04406 P00354 Q9HCU6 O14556 | 66% 65% 63% 63% |
| P07459 | Succinyl-coa synthetase alpha chain (SCS-ALPHA) | Q9BWB0 P53597 | 66% 66% |
| P11537 | Glucose-6-phosphate isomerase (GPI) | Q9UHE6 Q9BSK5 P06744 | 64% 64% 64% |
| P05042 | Fumarate hydratase Class II (fumarase) | AAH03108 P07954 | 60% 60% |
| P06994 | Malate dehydrogenase | AAH01917 P40926 | 58% 58% |
| P09148 | Galactose-1-phosphate uridylyltransferase | P07902 | 56% |
| P07912 | 2-amino-3-ketobutyrate coenzyme A ligase | O75600 | 55% |
| P08324 | Enolase (2-phosphoglycerate dehydratase) | P13929 | 55% |
| P10444 | Succinate dehydrogenase flavoprotein subunit | AAH01380 P31040 | 55% 55% |
| P25526 | Succinate-semialdehyde dehydrogenase [NADP+] (SSDH) | P51649 | 55% |
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Selected by two criteria: difference in length ≤10% and sequence identity ≥55%. Column names: Accession and Description as in Table 1; “Human homologs” contains the accession numbers for the corresponding human proteins; Identity is the percent identity from pairwise sequence comparison. Note that there may be multiple human homologs for a single E. coli enzyme. Table is sorted by sequence identity of the closest homolog.
