Cover image

High-density oligonucleotide arrays were used to identify genomic rearrangements that result in DNA sequence differences between humans and nonhuman primates. The cover depicts the hybridization of orangutan (top left) and chimpanzee (top right) DNA to a series of human chromosome 21 arrays. Analysis of these comparative array data demonstrated that genomic rearrangements (insertions and deletions ranging in size from 0.2–8.0 kb) are a significant source of DNA variation between humans and chimpanzees, as well as other nonhuman primates. (Cover created by Curtis R. Kautzer. [For details, see Frazer et al. pp. 341–346.])