Linkage Disequilibrium and Haplotype Diversity in the Genes of the Renin–Angiotensin System: Findings From the Family Blood Pressure Program

Table 1.

Genetic Polymorphisms in the RAS Genes, Whites and Blacks

Polymorphism (minor allele) dbSNP Whites Blacks δc
minor allele freq. HWE P value minor allele freq. HWE P value
REN
 C-4021T (T) 0.12 0.24 0.28 0.29 0.16
 C-3212T (T) 0.08 0.07 0.13 0.06 0.05
 A4280C (C) rs5705 0.12 1.0 0.30 0.08 0.18
 G5795T (G) rs5707 0.25 0.28 0.30 0.58 0.05
 C10377T (T) 0.12 0.23 0.18 0.63 0.06
AGTR1
 A-777T (A) rs275651 0.14 1.0 0.31 0.86 0.17
 G-680T (G) rs275652 0.14 0.2 0.26 0.18 0.12
 A-119G (G) rs275653 0.15 0.35 0.26 0.14 0.11
 C43732T (T) rs5182 0.50 0.64 0.21 0.07 0.29
 A44221G (G) rs5183 0.05 1.0 0.33 0.32 0.28
AGT
 C-532T (T) rs5046 0.12 0.23 0.11 1.0 0.01
 A-217G (A) rs5049 0.13 0.27 0.26 0.85 0.13
 A-6G (A) rs5051 0.48 0.12 0.84 0.80 0.36
 C3889T (C) rs4762 0.11 1.0 0.09 0.64 0.02
 C4072T (T) rs699 0.48 0.71 0.15 0.36 0.33
ACE
 A-239T (T) rs4291 0.47 0.42 0.34 0.26 0.13
 A7941G (G) rs4318 0.05 0.001 0.20 0.11 0.15
 C8342T (C) rs4321 0.39 0.87 0.38 0.74 0.01
 A10539G (A) rs4335 0.40 0.52 0.74 1.0 0.34
 A11599G (A) rs4343 0.42 0.42 0.73 0.86 0.31
 A12292G (A) rs4344 0.38 1.0 0.37 0.21 0.01
 A15990G (G) rs4353 0.39 0.86 0.35 0.44 0.04
 C17911T (C) rs4359 0.38 0.74 0.55 0.87 0.17
 C19329T (C) rs4362 0.40 0.002 0.54 0.65 0.14
 A20060G (A) rs4363 0.39 1.0 0.55 0.56 0.16

  • ↵Name given based on the position relative to exon 1 according to NCBI build number 30.

  • ↵SNP ID in database dbSNP.

This Article

  1. Published in Advance January 14, 2003, doi: 10.1101/gr.302003 Genome Res. 13: 173-181

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