Comparison of 10p11 with other human pericentromeric sequences. Annotations were taken from Deloukas et al. 2001; Hattori et al. 2000;Dunham et al. 1999; Guy et al. 2000; and Bailey et al. 2002. Additional annotations from the working draft April 2001 freeze (http://genome.ucsc.edu/) and ongoing chromosome specific programs (http://hgp.gsc.riken.go.jp/data_tools/data_chr21_seq_annotation.html,http://www.sanger.ac.uk/cgi-bin/humace/SuperMap22/) were also analyzed. Only gene annotations supported by both spliced ESTs and ab initio gene predictions are shown. These were analyzed further by aligning the ESTs which define the gene to all closely related genomic sequences within the human draft. On the basis of this, C20orf191 andMLLT10L, which map proximal of satellite sequences on chromosome 20 (Deloukas et al. 2001), were discounted as the ESTs which define these genes only share ∼95% identity to the chromosome 20 genomic sequence. The positions of major interchromosomal and intrachromosomal duplications are shown in dark and light grey respectively. The intrachromosomal duplications on 20p and 20q have also been duplicated interchromosomally. 526.1–ap000526.1,c22.4–ap000523.c22.4.
