Table 1.
Coregulated Gene Groups With Functional Relationships
|
EST ID |
Gene name |
Putative functional relationship |
|---|---|---|
| AI363200 | proenkephalin | Proenkephalin binds to G protein-coupled opioid receptors (Mansour et al. 1995). GAIP |
| AI363445 | G α interacting protein (GAIP) | is a regulator of G protein signaling (Berman et al. 1996). |
| AA464856 | inhibitor of DNA binding 4 | ID4 is known to induce apoptosis (Andres-Barquin et al. 1999). Caspase 5 is an |
| W60703 | caspase 5 | apoptosis-related cystein protease (Krippner-Heidenreich et al. 2001). |
| AI126424 | E2F-like protein | E2F-1 (Li and Baserga 1996) and Eps1 5R (Klapisz et al. 2002) are at the downstream of |
| AI92302 | eps1 5R | EGF signaling. |
| AI055825 | Low-affinity IgE Fc receptor | Fish odors or fumes cause allergic reaction through IgE-mediated hypersensitivity |
| AI251747 | odorant-binding protein 2B | (Crespo et al. 1995). |
| AA054073 | CEACAM6 | CEA/CEACAM6 and matrix metalloproteinases inhibit anoikis and enhance cell invasion |
| AA143331 | matrix metalloproteinase 1 | (Ordonez et al. 2000; Koul et al. 2001). |
| AI949576 | annexin A3 | Might be at common downstream of TGF-beta or glucocorticoid signaling. See text for |
| AI969825 | tumor antigen se20-4 | details. |
| AI971049 | myocilin | |
| AA422058 | methyltransferase-like 1 | DNA methylation inactivates metastasis suppressor genes (Lou et al. 1999). NM23B is |
| AA496628 | nonmetastatic cells 2, protein (NM23B) | found in reduced amount in tumor cells of high metastatic potential (Steeg et al. 1988) |
| AA398883 | squamous cell carcinoma antigen 1 | Cytokeratin 19 is a squamous cell carcinoma marker (Schneider et al. 2002). Therefore, |
| AA431080
|
keratin, type II cytoskeletal 6A
|
both gene products might be markers of squamous cell carcinoma.
|
