Table 1.
SVM Peformance in Distinguishing Real From Pseudo Exons
|
Flanks |
Splice sites |
|
|
|
||||
|---|---|---|---|---|---|---|---|---|
| US |
DS |
3′ |
5′ |
Exon body |
ROC |
Specificitya |
||
| CVb | 0.609 | 0.484 | ||||||
| + | - | - | - | - | 0.791 | 0.638 | ||
| - | + | - | - | - | 0.784 | 0.618 | ||
| + | + | - | - | - | 0.855 | 0.695 | ||
| - | - | + | - | - | 0.823 | 0.672 | ||
| - | - | - | + | - | 0.837 | 0.698 | ||
| - | - | + | + | - | 0.907 | 0.777 | ||
| + | + | + | + | - | 0.932 | 0.825 | ||
| - | - | - | - | + | 0.946 | 0.841 | ||
| + | + | - | - | + | 0.984 | 0.956 | ||
| - | - | + | + | + | 0.987 | 0.964 | ||
| +
|
+
|
+
|
+
|
+
|
0.991
|
0.976
|
||
-
Performances are indexed by ROC values and specificity. Each row is an SVM test. ROC values were measured in untouched sets of ∼2200 real and ∼2300 pseudo exons. The first five columns indicate the components used by SVM. US, upstream; DS, downstream; TP, true positive; FN, false negative; FP, false positive; SE, sensitivity; SP, specificity.
-
↵a Specificity = TP/(TP + FP) at a sensitivity (SE = TP/(TP + FN)) of 0.90
-
↵b The SVM classified on the basis of the acceptor and the donor consensus values
