DOTTER (version 3.1, default setting) dot-matrix comparison of the extended human and mouse MHC class III regions. The X-axis represents the mouse sequence, the Y-axis the human. The depicted human and mouse sequences begin at POU5F1 (in the class I region, for both human and mouse) and extend to TSBP. The location of the class III region to class I and II is indicated using arrows outside the top X-axis and left Y-axis. Only a portion of the human and mouse class I and II regions is included as indicated by the open arrows. GC contents were also determined and are shown above the axes. Arrows in the GC plots define the class III region as a GC-rich isochore. In mouse, the locations of the first class III gene, Bat1, and the last class III gene, Notch4, are shown as black boxes. There are a pair of short diagonal lines (see the arrows inside dot plots) away from the main diagonal axis, that correspond to the C4-CYP21 module (see text). Interspersed repeats are represented by the background dots.
