Table 3.
Source Gene Pairs With High Target Set Similarity Correspond More Frequently to Edges in Reference Networks (ppi1, ppi2, mips, mi2, mi3)
|
|
All pairs |
Confirmed pairs |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Reference network |
Total-all |
P ≤ 0.01 |
% all |
Total-conf |
P ≤ 0.01 |
% conf |
Increase % conf/% al |
||||
| A | B | C | D | E | F | G | |||||
| ppi1 | 10762 | 631 | 5.86 | 151 | 37 | 24.50 | 4.18 | ||||
| ppi2 | 5804 | 341 | 5.88 | 38 | 10 | 26.32 | 4.48 | ||||
| mips | 1283 | 75 | 5.85 | 31 | 15 | 48.39 | 8.28 | ||||
| mi2 | 8546 | 474 | 5.55 | 267 | 63 | 23.60 | 4.25 | ||||
| mi3
|
6701
|
400
|
5.97
|
172
|
50
|
29.07
|
4.87
|
||||
-
Columns A–C refer to all source gene pairs, where both genes are present in the particular reference network; columns D–F refer only to source gene pairs which are connected in the particular reference network (= confirmed source gene pairs). The proportion of pairs with highly similar target sets is increased between four- and eight-fold for the confirmed source gene pairs.
