Figure 2
Transcription factors with known binding sites and mutated genes form two sets of source genes (lefthand side). (A) The set T1 on the right represents all the genes in the genome that have binding sites for selected transcription factor s1 in their putative promoter regions (i.e., the target set of s1). The set T2 represents all the genes whose expression levels are changed in the deletion mutant of gene s2 (i.e., the target set of s1). If the target sets T1 and T2 overlap more than expected by chance, we can hypothesize that the two genes s1 and s2 are related. (B) The case when we compare two target sets from different networks, but for one gene s1.
