Parameter Estimation in Biochemical Pathways: A Comparison of Global Optimization Methods

Table 2.

Experiment Generation


P value

0.05

0.13572

0.36840

1.0
S value
0.1
0.46416
2.1544
10
Parameter
Element of decision variables vector
Nominal value
V1 p1 1
Ki1 p2 1
ni1 p3 2
Ka1 p4 1
na1 p5 2
k1 p6 1
V2 p7 1
Ki2 p8 1
ni2 p9 2
Ka2 p10 1
na2 p11 2
k2 p12 1
V3 p13 1
Ki3 p14 1
ni3 p15 2
Ka3 p16 1
na3 p17 2
k3 p18 1
V4 p19 0.1
K4 p20 1
k4 p21 0.1
V5 p22 0.1
K5 p23 1
k5 p24 0.1
V6 p25 0.1
K6 p26 1
k6 p27 0.1
kcat1 p28 1
Km1 p29 1
Km2 p30 1
kcat2 p31 1
Km3 p32 1
Km4 p33 1
kcat3 p34 1
Km5 p35 1
Km6
p36
1
  • S and P values were combined to generate a total of 16 sets of pseudoexperimental measurements, and nominal values of the parameters, also indicating the corresponding element of the decision variables vector (p).

This Article

  1. Genome Res. 13: 2467-2474

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