Parameter Estimation in Biochemical Pathways: A Comparison of Global Optimization Methods

Table 1.

Search Parameters Utilized in the Different Algorithms




SRES

uES

DE

CMA-ES
Search parameters G = 8000 G = 8000 VTR = 0.0; st = 6 N = 36
lambda = 350 lambda = 350 D = 36; NP = 450 lambda = 15
μ = 30; pf = 0.450 μ = 30 iterMax = 5000 μ = 7; xlow = xl; xup = xu
varphi = 1 varphi = 1 F = 0.5; CR = 0.55 MaxFunEvals = 3000N2

ICRS
MCS
GBLSOLVE

Search parameters e = 10−3 n = 36; smax = 370 eps_x = eps_f = 10−4
kl = 1 nf = 600 n2; stop(2) = 0 Iterations = 1500
k2 = 1/2 stop(1) = n + 2000

maxfsd = 4
iinit = 3; local = 15


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  1. Genome Res. 13: 2467-2474

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