Summary of the results of the consistency calculations for Escherichia coli. The results are presented in the form of fraction of consistent network elements for three different significance levels (P < 0.01, P < 0.005, P < 0.001). (A) Results for regulator modules classified by the mode of regulation of the regulator acting on the module. All, all modules with more than one target gene (number of regulator-target pairs n = 1355); Act, activator-regulated modules (844); Rep, repressor-regulated modules (455); Dual, dual function regulator-regulated modules (61). (B) Results for multiregulator modules shown for all modules as well as modules with different numbers of regulators (nreg). The results are only shown for cases with >10 instances of the module with the indicated number of regulators. The total number of target genes in multiregulator modules with more than one target is 658, and the numbers of target genes in multiregulator modules with different numbers of regulators are (in format: number of regulators [number of targets with this number of regulators]): 1 (368), 2 (142), 3 (71), 4 (46), and 5 (23). (C) Results for regulatory interactions classified by the mode of the regulator. The numbers of regulatory interactions in the network are: All (1367), Act (855), Rep (451), and Dual (61). In addition to the P-value threshold, results are also shown for consistency criteria utilizing both P-value threshold and sign criteria (s) as described in the text for pairwise correlations. (D) Results for target modules classified by the number of regulators acting on a target gene. The results are only shown for cases with >10 instances of the module with the indicated number of regulators. The numbers of target modules with different numbers of regulators are (in format: number of regulators [number of targets]): 1 (386), 2 (168), 3 (77), 4 (54), and 5 (25).
