Investigations Into the Analysis and Modeling of the TNFα-Mediated NF-κB-Signaling Pathway

Table 2.

Definition of Variables and Nominal Values for Parameters in Reaction Kinetics

Independent variables
Symbol
[μM−1sec−1]/[sec−1]
TNF/TNFR1 ratio k12_3/k3_12 0.00096/0.004
TNFR1/TRADD ratio k34_5/k5_34 0.00096/0.004
TRADD/FADD ratio k56_9/k9_56 0.00096/0.004
TRADD/RIP ratio k57_10/k10_57 0.00096/0.004
RIP/TRAF2 k810_11/K11_810 0.00096/0.004
TRAF2/IKK ratio k911_12/K12_911 0.00096/0.004
IKK activation ratio K12_13 0.1
IKK_act/(IκB/NF-κB) ratio K1314_15/k15_1314 0.00096/0.004
NF-κB activated ratio k15-1617 0.00096/0.004
Degradation ratio
k16
0.1

This Article

  1. Published in Advance January 1, 2003, doi: 10.1101/gr.1195703 Genome Res. 13: 2413-2422

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