Figure 6
Analysis of the 30 orthologous relations in the test set HOPS fails to find. The labels describe the reason for the misassignment. Of the 13 cases in which the HOPS clustering scheme is not reflected, eight go back to a single-domain family, the SM domain. Here the S. cerevisiae orthologs evolved much faster than the corresponding S. pombe ortholog. This leads to a tree in which only the S. pombe sequence is assigned as orthologous, but not the S. cerevisiae sequence. Other reasons are wrong rooting (five cases) of the tree and general low bootstrap support for the whole sequence family.
