Mutation Detection Using Mass Spectrometric Separation of Tiny Oligonucleotide Fragments

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Figure 4.
Figure 4.

Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) postsource decay (PSD) mass spectrum of oligonucleotides of identical nucleotide composition. Spectrum A is of a 6-mer of sequence CATCCT; spectrum B, a 6-mer of sequence CACCTT. Both have parent ion mass of 1727.2 Da. Observed masses are shown above the peaks. Fragments of PSD are shown at an intensity magnification of five.

This Article

  1. Published in Advance August 22, 2002, doi: 10.1101/gr.157802 Genome Res. 12: 1428-1433

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