Table 1.

Sequence Divergence of Ortholog Datasets

	Average length of coding sequences ^a (bp)	Number ^b	Nucleotide distance	Protein distance	K_a	K_S	K _a /K _S ^c	K _a /K _s
All orthologues	1245	4218	0.201	0.202	0.108	0.535	0.171	0.202
Orthologues with intermediate paralogue present in human	997	70	0.265	0.328	0.172	0.603	0.232	0.285
Orthologues with close paralogue present in human	909	180	0.194	0.190	0.100	0.526	0.168	0.190
Chimpanzee human orthologues	835	116	0.052	0.0824	0.028	0.052	0.640	0.538

^aGenes for which only partial coding sequence was available are included.
^bOnly gene pairs for which neither K_a nor K_S is saturated have been included.
^cAverage calculated over gene pairs for which K_S > 0.

Impact of the Presence of Paralogs on Sequence Divergence in a Set of Mouse-Human Orthologs