Comparative Genomic Sequence Analysis of the Human Chromosome 21 Down Syndrome Critical Region

Table 1.

Summary of Gene and Integenic Regions in the Human DSCR and the Corresponding Mouse Region

Gene Gene size (kb) Intergenic region size (kb)
human mouse human mouse
SIM2/Sim2 19.6 (14.4) 12.8 (11.9)
1.3 (1.3) 2.7 (2.5)
HLCS/Hlcs 211.0 (124.7) 139.4 (113.8)
44.4 (18.4) 59.5 (31.4)
DSCR6/Dscr6 13.1 (7.8) 8.1 (7.0)
45.7 (16.4) 27.5 (18.0)
DSCR5/Dcrc 7.7 (4.2) 6.3 (4.7)
12.7 (4.7) 13.2 (10.2)
TTC3/Ttc3 117.3 (73.5) 85.3 (71.3)
20.3 (8.6) 26.5 (17.0)
DSCR3/Dcra 44.1 (29.7) 28.4 (20.2)
100.0 (35.7) 84.1 (62.0)
DYRK1A/Dyrk1a 147.6 (93.1) 80.3 (65.4)
109.3 (54.4) 68.9 (50.1)
KCNJ6/Kcnj6 291.9 (184.6) 234.3 (182.5)
137.6 (71.7)
DSCR4 67.1 (37.5)
0.1 0 251.0 (181.2)
DSCR8 35.0 (20.0)
73.3 (38.9)
KCNJ15/Kcnj15 70.9 (52.3) 39.4 (35.1)
81.0 (48.9) 61.9 (49.5)
ERG/Erg 141.8 (103.8) 120.9 (102.0)
Total Size 1167.1 (745.5) 755.2 (613.9) 625.7 (299.0) 595.3) (421.9)
  • Numbers in parentheses indicate size of unique sequences that was calculated by subtracting all the repetitive sequences from entire sequences.

  • Only parts of the gene regions are included.

This Article

  1. Genome Res. 12: 1323-1332

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