Conserved Disruptions in the Predicted Coiled-Coil Domains of Eukaryotic SMC Complexes: Implications for Structure and Function

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Figure 5.
Figure 5.

COILS prediction of SMC5 and SMC6 orthologs. TheCOILS output for Homo sapiens SMC5 (a),H. sapiens SMC6 (b), Drosophila melanogasterSMC5 (c), C. elegans SMC6 (d), fission yeast (Schizosaccharomyces pombe) Spr18 (e), fission yeast Rad18 (f), budding yeast (Saccharomyces cerevisiae) Spr18 ortholog (g), and the budding yeast Rhc18 (h). The vertical axis denotes the probability of the amino acid sequence adopting a coiled-coil structure based on a scanning window of 28 residues. Conserved disruptions in the coiled-coil structure prediction to the SMC5/SMC6 SMC sequences are indicated beneath the COILSprofile with an asterisk.

This Article

  1. Genome Res. 12: 1201-1209

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