Comparison of the Small Molecule Metabolic Enzymes of Escherichia coli and Saccharomyces cerevisiae

Table 5.

Comparison of Domain Architectures in the 271 Groups of Common Enzymes

Type of group Number of groups Totals
Identical domain architecture and number of chains 80 Groups that have same or very similar
Different domain architecture, same number of chains, potentially same 16  domain architecture: 179
Same domains in a different order 4
Same domain architecture, yeast has more chains with this domain  architecture (likely larger number of isozymes) 26
Same domain architecture,E. coli has more chains with this domain  architecture (likely larger number of isozymes) 14
Same domain, but either the yeast or E. coli chain has two copies of the  domain (internal duplication) 2
Same domains, cases of gene fusion (These correspond to the cases listed in  Table 7; several common enzyme groups can correspond to one fusion  case.) 37
E coli has extra domains and/or chains 26 Groups that have shared domains and
Yeast has extra domains and/or chains 21  varied domains: 56
Both organisms have extra domains and/or chains 9
No domains shared (non-orthologous displacement) 13 Groups that do not share domains: 13
Potential cases of non-orthologous displacement (incomplete assignments) 6 Groups that cannot be classified: 23
Neither E. coli nor yeast chains have any assignment 2
Either yeast or E. coli chains have no assignment 15

This Article

  1. Genome Res. 12: 916-929

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