Comparative Sequence Analysis of the X-Inactivation Center Region in Mouse, Human, and Bovine

Table 2.

Assymetric distribution of LINEs on the two DNA strands

Region Species Length (kb) Gene orientation LINE+ LINE− χ2 P
Xpctgene human 147 − 47 20 10.88 <1%
mouse 117 + 11 51 25.81 <1%
intergene human 186 intergene 31 63 10.89 <1%
Xpct-Cnbp2 mouse 69 6 11 1.47 ns
intergene human 26 intergene 1 4 1.80 ns
Cnbp2-Ftx mouse 7 2 0 2.00 ns
Ftxgene human 14 + 2 6 2.00 ns
mouse 16 + 1 3 1.00 ns
intergene bovine 62 intergene 63 20 22.28 <1%
Ftx-Jpx human 425 70 192 56.81 <1%
mouse 114 9 13 0.73 ns
Jpxgene bovine 16 − 22 4 12.46 <1%
human 68 − 49 30 4.57 <5%
mouse 9 − 2 0 2.00 ns
intergene bovine 38 intergene 5 13 3.56 ns
Jpx-Xist human 95 32 58 7.51 <1%
mouse 10 0 2 2.00 ns
Xistgene bovine 35 + 0 7 7.00 <1%
human 32 + 0 8 8.00 <1%
mouse 23 + 0 0 nd
intergene bovine 82 intergene 49 31 4.05 <5%
Xist-Tsx human 38 7 3 1.60 ns
(Tsixgene) mouse 35 − 14 3 7.12 <1%
Tsxgene human 44 − (pseudo) 26 4 16.13 <1%
mouse 10 − 2 1 0.33 ns
intergene human 70 intergene 31 7 15.16 <1%
Tsx-Chicl mouse 25 1 1 0.00 ns
Chiclgene human 157 − 61 36 6.44 <5%
mouse 32 − 8 5 0.69 ns
intergene human gap intergene nd nd nd
Chicl-Cdx4 mouse 27 1 18 15.21 <1%
Cdx4-gene human 7 − 0 1 1.00 ns
mouse 8 − 1 0 1.00 ns
intergeneCdx4-NapIl2 human 193 intergene 47 84 10.45 <1%
intergene mouse 77 intergene 10 42 19.69 <1%
Cdx4-Ppnx
Ppnxgene mouse 74 + 1 36 33.11 <1%

  • LINE+, number of LINEs on the direct strand; LINE−, number of LINEs on the complementary strand. P; probability, ns; not significant, nd; not done.

This Article

  1. Published in Advance November 21, 2000, doi: 10.1101/gr.152902 Genome Res. 12: 894-908

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