Table 3.
Differentially Expressed Genes
| Gene # | Unigene symbol | Accession no. | Gene name (and function) |
| Miscellaneous (11 genes) | |||
| 7 | Abca2 | AA276158 | ATP-binding cassette, sub-family A (ABC1), member 2 (member of ABC transporter family) |
| 33 | A1p2a2 | AA222567 | ATPase, Ca2+transporting, cardiac muscle, slow twitch 2 (endo/sacrooplasmic reticulum calcium pump) |
| 9 | C1r | AA261393 | Complement component 1, r subcomponent (activation of classical complement cascade) |
| 3 | Lrpap1 | AA253890 | Low-density lipoprotein receptor-related protein associated protein 1 (chaperone for LDL receptor family members) |
| 31 | Papss2 | AA244536 | 5′-Phosphoadenosine 5′-phosphosulfate synthase 2 (sulfation of toxins) |
| 35 | Pglyrp | AA238752 | Peplidoglycan recognition protein (innate immunity; recognizes bacterial wall peptidoglycan) |
| 11 | Psme1 | AA239485 | Protease (prosome, macropsin) 28 subunit, α (activator subunit of 205 proteasome) |
| 1 | Pura | AI894064 | Purine-rich element-binding protein A (single-stranded-DNA, and RNA-binding protein) |
| 23 | Rdh5 | AA275664 | Retinol dehydrogenase type 5 |
| 20 | Rps5 | AA240279 | Ribosomal protein S5 (translation) |
| 5 | X66 | AA249976 | Xeroderma pigmentosum, complementation group C (DNA excision repair) |
| Transcription (6 genes) | |||
| 22 | Hdac5 | AA017742 | Histone deacetylase 5 (regulation of transcription) |
| 25 | Klf1 | W97446 | Erythroid Kruppel-like factor 1 (transcriptional activator of the adult β-globin promoter) |
| 28 | Mata1l1 | AA461637 | Metastasis associated 1-like 1 (modulates histone deacetylase complex NuRD) |
| 34 | Mxl1 | AA472395 | Ma-interacting protein 1 (antagonist of c-Myc transcription factor) |
| 8 | Nr2c2 | AA501045 | Nuclear receptor subfamily 2, group H, member 2 (steroid receptor superfamily member) |
| 28 | Sp1 | AA212645 | trans-Acting transcription factor 1 (zinc-finger transcription factor) |
| Cell morphology (5 genes) | |||
| 13 | Cdc42 | AA266975 | Cell division cycle 42 homolog (ρ GTPase, cell morphology) |
| 15 | Crkas | AA240272 | v-crk associated tyrosine kinase substrate (focal adhesion docking protein p130(Cas), cell morphology, modulation cytoskeleton) |
| 18 | Mlapt/Mapl | AA028410 | Microtubule-associated protein τ (modulation cytoskeleton) |
| 27 | Pkcq | W98195 | Protein kinase C, theta (modulation of cytoskeleton, neurite outgrowth) |
| 30 | Stk2 | AA268478 | Serine/threonine kinase 2 (apoptosis, cytoskeletal remodeling) |
| Extracellular matrix/cell adhesion (3 genes) | |||
| 2 | Ecm1 | AA237378 | Extracellular matrix protein 1 (secretory glycoprotein) |
| 14 | Eln | AA239171 | Elastin (extracellular matrix component) |
| 36 | Lamc2 | W49392 | Laminin, γ2 (extracellular matrix glycoprotein; major constituent basement membranse) |
| Signal transduction (3 genes) | |||
| 16 | Grb2 | AA183927 | Growth factor receptor bound protein 2 (adaptor protein involved in signal transduction) |
| 32 | Ppp2ca | AA245165 | Protein phosphatase 2a, catalytic subunit, α isoform (signal transduction, apoptosis) |
| 29 | S100a6 | AA267952 | Calcium-binding protein A6, or calcyclin (calcium signal transduction) |
| Apoptosis (2 genes) | |||
| 19 | Parg | AA260570 | Poly(ADP-ribose) glycohydrolase (catabolism of poly(ADP-ribose), apoptosis) |
| 6 | Siah1a | AA267965 | Seven in absentia homolog 1A (apoptosis, cell cycle arrest ubiquitin-proteasome pathway) |
| Intermediary metabolism (2 genes) | |||
| 4 | Mor1 | AA266087 | Mitochondrial malate dehydrogenase (oxidative phosphorylation) |
| 17 | Mu1 | AA250181 | Methylmalonyl-coenzyme A mutase (isomerization succinyl CoA and methylmalonyl CoA) |
| RNA binding (2 genes) | |||
| 12 | Fxr2h | AA119248 | Fragile X mental retardation gene, autosomal homolog 2 (RNA binding protein) |
| 21 | qk | AA220551 | Quaking (RNA binding protein required for myelin formation, apoptosis) |
| Vesicular transport (2 genes) | |||
| 10 | Ap1b1 | AA221073 | Adaptor protein complex AP-1, β1 subunit (clathrin-coated vesicle formation) |
| 24 | Arf2 | AA266938 | ADP-ribosylation factor 2 (GTP-binding protein, formation of coated transport vesicles) |
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Gene number is the rank of the gene in order of most (gene 1) to least (gene 36) (p < 10−6) significantly differentially expressed between the normal and MA brains; see Fig. 8B. For table, genes are ordered alphabetically within categories.
