Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter pylori Using Genome-Scale Extreme Pathway Analysis

Table 2.

Extreme Pathway Characteristics Associated with the Production of the Indicated Amino Acids

Amino Acid Case 1 Case 2 Case 3 Case 4
no. of EP no. of ES no. of EP/ES no. of EP no. of ES no. of EP/ES no. of EP no. of ES no. of EP/ES no. of EP no. of ES no. of EP/ES
Asparigine 217 105 2.1 295 154 1.9 295 154 1.9 340 193 1.8
Aspartic Acid 360 102 3.5 466 142 3.3 466 142 3.3 491 163 3.0
Cysteine 473 232 2.0 822 420 2.0 822 420 2.0 1022 612 1.7
Glutamine 249 101 2.5 290 140 2.1 290 140 2.1 315 164 1.9
Glutamic Acid 441 148 3.0 473 178 2.7 473 178 2.7 493 198 2.5
Glycine 0 ··· ··· 0 ··· ··· 348 149 2.3 377 173 2.2
Lysine 474 167 2.8 587 213 2.8 587 213 2.8 611 237 2.6
Proline 479 149 3.2 621 209 3.0 621 209 3.0 867 326 2.7
Serine 212 101 2.1 326 158 2.1 326 158 2.1 355 186 1.9
Threonine 275 136 2.0 432 206 2.1 432 206 2.1 469 242 1.9
Tryptophan 936 615 1.5 1431 1034 1.4 1431 1034 1.4 1958 1486 1.3
Tyrosine 584 302 1.9 825 477 1.7 825 477 1.7 1008 649 1.6
Average 392 196 2.4 547 303 2.3 576 290 2.3 692 386 2.1

  • The various cases refer to changes in the carbon sinks of the network (see Fig. 2). Case 1: succinate; Case 2: succinate, acetate; Case 3: succinate, acetate, formate; Case 4: succinate, acetate, formate, lactate. EP indicates extreme pathway in above table; and ES, unique external state.

This Article

  1. Published in Advance April 12, 2002, doi: 10.1101/gr.218002 Genome Res. 12: 760-769

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