Structure and Evolution of the Smith-Magenis Syndrome Repeat Gene Clusters, SMS-REPs

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Figure 1.
Figure 1.

An example of a cis-morphism among three SMS-REPs. Southern blotting with CLP cDNA probe on HindIII-digested large-insert genomic clones revealed an 8.1-kb band for the distal SMS-REP (lanes 3 and 4 for yeast artificial chromosomes [YACs]; lanes 7 and 8 for bacterial artificial chromosomes [BACs]) and 5.1 kb and 0.9 kb for the proximal SMS-REP (lanes 5 and 6 for YACs; lanes 9 and10 for BACs). Hybridization to total genomic DNA (gDNA in lanes 1 and 2) reveals additional cross-hybridizing bands, which map to different genomic locations.

This Article

  1. Genome Res. 12: 729-738

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