Identification of a Novel cis-Regulatory Element Involved in the Heat Shock Response in Caenorhabditis elegans Using Microarray Gene Expression and Computational Methods

Table 1.

Genes Up-Regulated on Heat Stress

Gene Average fold increase (5 experiments ± SD) Average fold increase (2 × 1 hr experiments) Average fold increase (3 × 4 hr experiments) HSE sites? HSAS sites? Function
F44E5.5 52.1 ± 52.8 78.5 32.9 + + Member of Hsp70- protein family
T27E4.2 51.2 ± 31.9 92.2 25.2 + + Member of Hsp-16- protein family
F44E5.4 49.4 ± 39.2 85.5 25.3 + + Member of Hsp70- protein family
F08G2.5 9.8 ± 8.8 5.5 12.6 + + Predicted coding sequence, unknown function
C50F7.5 8.8 ± 6.2 2.3 13.1 + + Predicted coding sequence, unknown function
T27F2.4 6.5 ± 5.1 2.4 9.2 + + Predicted coding sequence, unknown function
Y38H6C.7 5.6 ± 3.2 7.5 4.3 + Predicted coding sequence, unknown function
H14N18.1 5.1 ± 3.1 4.5 5.4 + unc-33(bag-2). Muscle function, HSP70 regulator
F58E10.4 4.7 ± 2.5 2.5 6.1 + + aip-1.arsenite resistance
M05D6.1 4.6 ± 3.5 8.4 2.1 + + Ser/Thr Kinase
F33H12.6 4.5 ± 2.4 6.0 3.6 + + Predicted coding sequence, unknown function
F09B9.1 4.4 ± 4.5 2.4 5.8 + Predicted G-protein linked receptor
R07B1.4 4.3 ± 2.9 1.8 5.9 + + Glutathione S-transferase
M01B12.1 4.1 ± 4.1 3.0 4.8 + Predicted coding sequence, unknown function
F30F8.4 3.8 ± 2.1 6.0 2.4 Member of transposase protein family
D2013.9 3.8 ± 1.3 3.5 4.0 + Predicted coding sequence, unknown function
C12C8.1 3.6 ± 2.5 6.1 2.0 + Member of Hsp70- protein family
C30C11.4 3.2 ± 1.3 4.4 2.4 + + Member of Hsp70- protein family
F53A9.2 3.2 ± 1.5 3.8 2.8 + + Predicted coding sequence, unknown function
C25F9.2 3 ± 1.5 2.9 3.0 + Predicted coding sequence, unknown function
T27A3.4 2.9 ± 2.3 3.4 2.5 Predicted coding sequence, unknown function
F41C3.2 2.4 ± 0.9 2.3 2.4 + Identified as sodium/phosphate transporter protein
T28H11.7 2.3 ± 1.4 2.1 2.5 + Predicted coding sequence, unknown function
F55A12.9 2.3 ± 0.6 2.6 2.0 Predicted coding sequence, unknown function
W02D9.10 2.2 ± 0.4 1.8 2.5 + Predicted coding sequence, unknown function
R03D7.2 2.1 ± 0.9 2.1 2.1 + + Identified as putative helicase
ZK1290.5 2 ± 0.5 1.7 2.3 + Identified as aldo/keto reductase.
C25D7.1 2 ± 1.0 1.7 2.2 Predicted coding sequence, unknown function

This Article

  1. Genome Res. 12: 701-712

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