Complex SNP-Based Haplotypes in Three Human Helicases: Implications for Cancer Association Studies

Table 3.

EMHAPFRE Inferred Haplotypes for BLM, WRN, andRECQL

BLM WRN RECQL
H N H N H N
CEPH 16(19)  78(194) 20(21)  78(194) 15(16)  68(178)
Af-American 22 146 23 154 21 156
Asian 16  78 14  78 10  74
Caucasian 25 152 29 158 20 156
Hispanic 22 144 21 150 27 152
Combined 50 598 56 618 47 616
Shared Haplotypes 5 4 6

  • CEPH haplotype numbers inferred manually are in brackets; CEPH grandparents were used for EMHAPFRE prediction. The combined haplotype number was obtained when all ethnic samples and the CEPH grandparents were analyzed by EMHAPFRE. H denotes haplotypes andN the number of chromosomes used in each sample group. The number of CEPH chromosomes in parentheses reflects all family members to distinguish from the number present in the grandparents.

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  1. Genome Res. 12: 627-639

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