A Genome-Wide Screen for Normally Methylated Human CpG Islands That Can Identify Novel Imprinted Genes

Table 1.

Methylated CpG Islands Characterized in Detail

Clone ID Methylation pattern Chromosomal location Associated genes
Accession no. Predicted function
3-10 SMR 1q44 14042537 Similar to Zn finger protein
14423768 Olfactory receptor 2T1
hCG1644736 Similar to olfactory receptor 2T1
hCG1724357 Similar to olfactory receptor 2T1
3-20 SMR 2q36 5174481 Histone deacetylase A
hCG1651464
hCG1656118
hCG1651461
hCG1651466
1-19 SMR 4p16 3777583 WFS1 (wolframin)
1-41 SMR 4q35 hCG1788598 Similar to mouse pair-rule gene ODZ3
hCG1793025 Hypothetical protein
hCG1787540 Similar to mouse pair-rule gene ODZ3
4-8 SMR 4q35 hCG1788598 Adjacent to but distinct from 1-41
3-4 gDMR 6q24 hCG1660630 HYMA1
4-7 SMR 7p22 6806913 Centaurin-α
hCG1747708
hCG1790856
hCG1747710 Cytochrome P450 homolog
1-30 SMR 7q11.1 hCG1779529 Rab5 exchange factor homolog
hCG1779527 Antisense to hCG1779529
hCG1789113 Antisense to hCG1779529
13642872 60S ribosomal prot L35
6572672 Putative transcription factor
1-22 SMR 7q36 11386149 Tyrosine phosphatase
hCG1799787 BHLF1 protein
3-2 SMR 8p23 hCG1659058 Proline-rich mucin homolog
2-5 gDMR 8q21.2 17451956 Similar to antigen GOR
hCG1757665
2-48 gDMR 9p13 hCG1659616
1-20 gDMR 10q26 13325182
hCG1799063
3-12 SMR 10q26 3122245 Inositol triphosphate phosphatase
hCG1654478
3-30 gDMR 11q25 17456499 Hypothetical gene
hCG37607
hCG1745526 Hypothetical protein
1-5 SMR 13q34 hCG20146
1-21 gDMR 14q32 8393715 Heptacellular cancer candidate
hCG21408 Similar to DrosophilaCLIP-190
2-42 gDMR 16p13.1 hCG15669 Ser/Thr protein kinase
3-110 SMR 17q25 8400736 β-tubulin cofactor D
10435982
2-1 SMR 17q25 1655842 Sulfamidase
14149793 Coiled-coil protein
1-12 SMR 17q25 hCG1806389
hCG1796817
2-78 gDMR 18q21 13645769 Elongin A3
3-8 gDMR 18q21 13645769 Adjacent to but distinct from 2-78
2-3 SMR 18q23 6912444 Voltage-dependent K+ channel
1914872 Choline-binding protein
5326898 RNA Polymerase II CTD phosphatase
1-13 gDMR 18q23 hCG1651089
6688241 SALL3 Spalt-like zinc finger protein
hCG20372 ATPase
1651088 Mucin1 precursor
1-6 gDMR 19p13.1 14249150 Hypothetical protein
4-3 SMR 19p13.3 9665054 Ser/Thr kinase 11
hCG23965 Ankyrin repeat protein
4506715 Ribosomal protein S28
hCG1794585
10732648 Angiopoietin-like protein
1-2 SMR 19q13.4 12053197 Zinc finger protein
4505329 NSF attachment protein
5901994 Kaptin-actin binding protein
5689511 Na/Ca exchanger protein
7657128 Glioma tumor suppressor candidate
7657054 EH-Domain containing protein
7657130 Glioma tumor suppressor candidate
2-4 gDMR 20q12 17484155 Nuclear factor of activated T-cells 2
hCG1800975
hCG1653833
13378306 Brain RPTmam4 isoform
110743 Neurofilament triplet H protein
7799072 DNA helicase
  • Accession numbers correspond to GenBank entries, within 10 kb of the CpG island, unless there is no GenBank entry, in which case they correspond to Celera entries. One additional SMR could not be mapped.

  • CpG island lies within the transcript.

This Article

  1. Genome Res. 12: 543-554

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