A Genome-Wide Screen for Normally Methylated Human CpG Islands That Can Identify Novel Imprinted Genes

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Figure 8.
Figure 8.

Sequence conservation of methylated CpG islands between human and mouse. Human methylated CpG islands and ∼1 kb of flanking DNA were compared to mouse sequence, synteny was confirmed, the corresponding mouse CpG islands were identified, and regions of conservation (percentage shown) were determined. In the case of gDMR 1–21, the corresponding mouse sequence, while GC-rich, showed an observed to expected CpG ratio of 0.45–0.50 and therefore was not classified as a CpG island. Colors are as indicated in the figure.

This Article

  1. Published in Advance March 20, 2002, doi: 10.1101/gr.224102 Genome Res. 12: 543-554

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