Consensus Promoter Identification in the Human Genome Utilizing Expressed Gene Markers and Gene Modeling

Table 3.

Searching Promoters for Genes with Known 3′ ESTs

Programs Training set of 118 promoters Test set of 120 promoters
true prediction (sensitivity) false prediction (FP/All P) undetected true prediction (sensitivity) false prediction (FP/All P) undetected
PROSCAN1.7 15 (13%) 17 (53%) 99 12 (10%) 21 (64%) 97
NNPP2.0 33 (28%) 43 (57%) 56 20 (17%) 67 (77%) 45
PromFD1.0 38 (32%) 33 (46%) 78 36 (30%) 61 (63%) 62
promoter2.0 6 (5%) 99 (94%) 13 7 (6%) 104 (94%) 9
TSSG 39 (33%) 11 (22%) 68 32 (27%) 30 (48%) 58
TSSW 32 (27%) 19 (37%) 67 27 (23%) 31 (53%) 62
CONPRO 45 (38%) 6 (12%) 67 44 (37%) 8 (15%) 68
  • CONPRO predicts promoters for about 37% human genes. Of all the predictions made by CONPRO, about 85% are correct. Additional information is given in the legend of Table 1.

This Article

  1. Genome Res. 12: 462-469

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