Figure 1.
Improved allele recognition by oligonucleotide array. Allele combination of HLA-B*1502 and B*2702 share the same polymorphisms with combinations of B*1513 and 2708 (polymorphic sites are shown in bold). Both allele combinations show the same sequence pattern (top) and cannot be distinguished by sequencing method. When hybridized with oligonucleotide arrays, these two combinations show different hybridization pattern (bottom). Combination of B*1502 and B*2702 is represented by probe M3 and M8, while combination of B*1513 and B*2708 is represented by probe M1 and M3 (see Table 1).
