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Multi-pronged statistical analyses were performed to detect quantitative trait loci controlling the immobility times in forced swimming test (FST) and tail suspension test (TST). These two paradigms are widely used for the screening of antidepressive drugs, and immobility in both tests is thought to be related to the propensity for despair. The mice used as F0 are C3H/He (C3) (upper left) and C57BL/6 (B6) (lower right). The lower left triangle shows the results of two-locus interaction analysis of the B6 × B6 genotypes for the TST immobility with red circles indicating the locus combinations for a genome-wide significance. The upper right triangle shows results of the C3 × C3 genotype interactions in the TST immobility. The middle inset is the result of the genome scan by using composite interval mapping for both FST and TST immobilities. (For details, see Yoshikawa et al., pp. 357–366.)