Numbers of Pseudogenes and Genes
| Type of (pseudo)genes | Predictions for chromosomes | Extrapolation or prediction | ||
| 21 | 22 | 21 + 22 | Whole human genome | |
| GenomeScan genes | 279 | 648 (593) | 927 (872) | 38,647 (∼26,000–28,000) (∼20,000–25,000) |
| Processed pseudogenes | 77 [65] | 112 [83] | 189 [148] | ∼6100–6600 (based on chromosome 21 data) ∼8700–9400 (based on chromosome 22 data) |
| Nonprocessed pseudogenes | 72 [64] | 123 [83] | 195 [147] | ∼5700–6200 (based on chromosome 21 data) ∼9600–10,400 (based on chromosome 22 data) |
| Pseudogenic Ig segments | — | 70 | 70 | — |
| GenomeScan genes, removing those that overlap with our pseudogenes (above) | 226–257 | 437–551 | 663–808 | — |
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↵Supplied by C. Burge and R.-F. Yeh (personal communication). See (Yeh et al., 2001) for details of the program GenomeScan.
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↵The figures in brackets give the totals omitting the Sanger (chromosome 22) and Riken (chromosome 21) pseudogene annotations.
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↵These are the ranges estimated for total number of genes byYeh et al. (2001), first, if overparsing of gene structures is taken into account (i.e., splitting up genes into smaller genes) and, second, if the expected rates of false-positives and pseudogenes are taken into account [see Yeh et al. (2001) for details].
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↵The Riken and Sanger Centre annotations are merged with our own annotations. The pseudogenic immunoglobulin gene segments are taken out of these totals.
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↵Based on data for either chromosomes 21 and 22, omitting immunoglobulin gene segments for the nonprocessed pseudogene estimate.
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↵This does not include immunoglobulin gene segments on chromosome 22. The lower bound arises from discarding predicted genes that have any predicted pseudogenic exon. The upper bound is for predicted genes that are judged disabled in each exon, or only comprise an isolated disabled fragment (such as a processed pseudogene or an isolated disabled exon).
