Table 3.
Well-Characterized Interaction of Protein Pairs and the Submembrane Localization Predicted by Domains
| A. Interaction of Proteins Containing PDZ Domain and C-Terminal Tails | ||||
| Bait | C-Terminus | Consensus | Class of PDZ domain | Prey |
| KIAA0343 | −SFV | S/T-X-I/V | Class I | KIAA1634(6) |
| KIAA0578 | −YYV | F/Y-X-A/F/V | Class II | KIAA0300(1), KIAA0440(1) |
| KIAA0816 | −SQV | S/T-X-I/V | Class I | KIAA1526(2) |
| KIAA1132 | −TLV | S/T-X-I/V | Class I | KIAA0705(8), KIAA1634(14) |
| KIAA1206 | −TDL | S/T-X-I/V | Class I | KIAA0380(5), KIAA0705(1), KIAA1634(3) |
| KIAA1278 | −HSM | — | Class new | KIAA0316(2), KIAA0807(3) |
| KIAA1763 | −YFF | F/Y-X-A/F/V | Class II | KIAA0561(1) |
| B. Interaction of Proteins Containing SH3 and Cytoplasmic Domains | ||
| Bait | Alias | Prey |
| KIAA0348 | Synaptojanin 2 | KIAA1256(3) |
| KIAA0960 | — | KIAA0400(2) |
| KIAA1368 | Semaphorin 6A | KIAA0777(1), KIAA1256(1), KIAA1296(6), KIAA1494(6) |
| KIAA1549 | — | KIAA1256(1) |
| C. Interaction Pairs in Which the Prey Contains a Domain Associated with the Membrane and/or Located in Structural Complexes Near the Submembrane Region | |||
| Bait | Prey | Domain | Accession number |
| KIAA0319 | KIAA0396 | Ankyrin repeat | PF0023 |
| KIAA1299 | Pleckstrin homology (PH) domain | PF00169 | |
| KIAA0343 | KIAA1251 | Spectrin repeat | PF00435 |
| KIAA0348 | KIAA1256 | Dbl domain (dbl/cdc24 rhoGEF family) | PF00621 |
| Pleckstrin homolog (PH) domain | PF00169 | ||
| KIAA0463 | KIAA1374 | G-protein β WD-40 repeats | PS50294 |
| KIAA0812 | KIAA0640 | Pleckstrin homolog (PH) domain | PF00169 |
| KIAA0728 | Spectrin repeat | PF00435 | |
| KIAA0868 | KIAA1251 | Spectrin repeat | PF00435 |
| KIAA0921 | KIAA1251 | Spectrin repeat | PF00435 |
| KIAA0960 | KIAA0400 | Ankyrin repeat | PF00023 |
| Pleckstrin homolog (PH) domain | PF00169 | ||
| KIAA1132 | KIAA0705 | Guanylate kinase | PF00625 |
| KIAA1092 | Pleckstrin homology (PH) domain | PF00169 | |
| Phosphatidylinositol-specific phospholipase C | PF00388 | ||
| KIAA1206 | KIAA0380 | Dbl domain (dbl/cdc24 rhoGEF family) | PF00621 |
| KIAA1216 | KIAA1037 | G-protein β WD-40 repeats | PS50294 |
| KIAA1368 | KIAA1256 | Dbl domain (dbl/cdc24 rhoGEF family) | PF00621 |
| Pleckstrin homolog (PH) domain | PF00169 | ||
| KIAA1549 | KIAA0728 | Spectrin repeat | PF00435 |
| KIAA1746 | KIAA0465 | Spectrin repeat | PF00435 |
| KIAA1763 | KIAA1251 | Spectrin repeat | PF00435 |
| KIAA1780 | KIAA0207 | Pleckstrin homology (PH) domain | PF00169 |
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↵Only proteins containing the PDZ are listed. Classification criteria of Tochio et al. (1999) for the PDZ domain target sequence was used.
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↵Did not exactly match class I consensus sequence, but was categorized as class I according to Harris and Lim (2001).
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↵Only proteins containing the SH3 domain are described.
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↵This list also contains domains aside from the domains in the interaction region. PDZ and SH3 domains that are described in Parts A and B are not included.
