Novel PAX6 Binding Sites in the Human Genome and the Role of Repetitive Elements in the Evolution of Gene Regulation

Table 1.

PAX6-Binding Sequences in the Human Genome

Name sc-DNA library Sequence (5′–3′) Homology to SINE Location Binding specificity Binding affinity
GCα1BLs5 MboI TTAGTTCCAGGTCAG Rodent B1 Intron 6 ofGCα1 PAX6 0.60
Tsp11Bs Tsp509I AATTAGCCAGGCATGGTAGCACA Primate Alu Multiple PAX6 0.56
Mse180B1s MseI TACAAGCTTCCGCATGAATGGTGCTGGT None Intron 6 ofCyp39A1 PD6 0.65
Tsp2As1 Tsp509I GGCCAGTCACGCGTGTAATT None AL157938 PAX6 1.5

  • ↵Data from Zhou et al. (2000).

  • ↵Binding affinity to PAX6 relative to CD19-2(A).

This Article

  1. Genome Res. 12: 1716-1722

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