Systematic Learning of Gene Functional Classes From DNA Array Expression Data by Using Multilayer Perceptrons

Table 2.

The 20 Classes With Higher Rate of True Positives Learned by the Multilayer Perception (MLP) With an Output Threshold of τ = 0.5.

Class Class size True positive (%) True negative (%)
Ribosomal proteins 170 79.6 97
Mitochondrial organization 294 54.6 90.6
Organization of cytoplasm 462 52.8 84.8
Nuclear organization 645 50.2 76.8
Tricarboxylic-acid pathway 17 47.6 99
C-compound and carbohydrate transporters 31 43.2 97.8
rRNA transcription 95 41.8 95.2
Respiration 54 41.2 96.8
mRNA transcription 427 38.4 80.2
Peroxisomal organization 33 37.8 97.4
Organization of endoplasmatic reticulum 134 36.6 94.2
Organization of chromosome structure 27 36.2 97.4
Glyoxylate cycle 5 35 99
Proteolysis 116 33.4 94.8
Glycolysis and gluconeogenesis 29 32 98.2
C-compound and carbohydrate metabolism 258 31.8 87.2
Amino acid metabolism 157 31 92.8
Stress response 90 28 95
Nitrogen and sulphur metabolism 50 27.8 97.2
Organization of plasma membrane 110 26 94.2
  • The second column lists the number of genes in the class listed in the first column. The entries in the third and fourth columns are averages over five realizations of the three-fold cross-validation scheme.

This Article

  1. Genome Res. 12: 1703-1715

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