Genomic Structure and Evolution of the Ancestral Chromosome Fusion Site in 2q13–2q14.1 and Paralogous Regions on Other Human Chromosomes

Table 1.

Extent and Degree of Sequence Similarity Among Paralogous Blocks Related to 2qFus

2q11.2-A 34G16 AC008268 2q11.2-B 468G5 AC009238 9pter 174M15/143M1 AL356244/AL449043 9q13 561O23/88I18/274B18 AL353608/AL161457/AL353616 (9p11.2)-A 15J10 AL512605 (9p11.2)-B 403A15 AL445925 (19pter) 34P13 AL627309 22qter n1g3/n94h12 AC002055/AC002056
2qFus ≥97.5 kb 95.8% [355, 2740] 20.5kb 96.0% [84, 278] ≥167.8 kb 98.9% [257, 6822] ≥149.4 kb 98.2% [270, 12821] ≥42.3 kb 98.5% [63, 541] ≥62.5 kb 98.1% [240, 12524] ≥29.5 kb 98.8% [41, 104] ≥67.3 kb 98.6% [83, 3715]
2q11.2-A ≥16.1 kb 99.0% [22, 76]
9pter ≥150.5 kb 98.2% [321, 12908] ≥42.1 kb 98.4% [71, 413] ≥64.2 kb 98.1% [224, 12100] ≥8.5 kb 99.6% [6, 11]
9q13 ≥42.4 kb 99.0% [75, 380] ≥109.8 kb 98.8% [193, 1286]
9p11.2-A ?
  • Extent of homology and percent identity of paralogous blocks related to 2q13–q14.1 fusion region. Only base substitutions, not insertions or deletions, are considered in the calculations of percent identity (see Methods section). The number of insertions or deletions and the total number of bases in these gaps are given in brackets. The extent of homology is defined by the sequence indicated at the beginning of each row and is a minimal estimate in all but one case, since available sequence terminates within the regions of homology. All clones are from the RP11 BAC library except the chromosome-22 cosmids, n1g3 and n94h12.

This Article

  1. Genome Res. 12: 1651-1662

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