Signatures of Domain Shuffling in the Human Genome

Table 7.

Observed and Expected Numbers of 0–0 and 1–1 Symmetrical Class 1 and Class 2 Domains inC. elegans

Category Comb. Obs. Exp. P
Class 1 domains
 Domain (83) 0–0 13 8.7 0.13
1–1 36 25.5 <0.05
2–2 2 1.2 n.d.
Formula 51 35.4 <10−3
 Domain family (41) 0–0 9.9 8.5 0.59
1–1 10.7 6.1 <0.05
2–2 0.8 0.9 n.d.
Formula 21.4 15.5 0.06
Class 2 domains
 Domain (81) 0–0 13 7.1 <0.05
1–1 21 17.5 <0.34
2–2 5 4.3 n.d.
Formula 39 28.9 <0.05
 Domain family (47) 0–0 8.3 4.7 0.11
1–1 10.7 8.4 0.38
2–2 4.3 3.2 n.d.
Formula 23.3 16.3 <0.05
  • Total numbers of domains in each category are indicated in parentheses. Summed combinations of symmetrical domains are shown in boldface. Note that only class 2 domains encoded by 2 exons are considered here (see text for details). (Comb.) Combinations; (Obs.) observed; (Exp.) expected.

This Article

  1. Genome Res. 12: 1642-1650

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