Signatures of Domain Shuffling in the Human Genome

Table 6.

Observed and Expected Numbers of Old and New Domains and Families in Humans That Are Bounded Symmetrically by Phase 0, Phase 1, or Phase 2 Introns

New Old
Domain (222) Family (36) Domain (401) Family (95)
Obs. Exp. P Obs. Exp. P Obs. Exp. P Obs. Exp. P
0–0 13 32.6 <10−3 4.6 8.9 0.1 80 71 0.19 27.5 23.4 0.33
1–1 138 109.5 <10−3 15.4 7 <10−3 125 148.7 <0.02 11.5 18.5 0.07
2–2 3 4.8 n.d. 1.2 1.4 n.d. 13 11.8 0.72 3.9 3.7 n.d.
  • Total numbers in each category are indicated in parentheses. The expected numbers are based on the fraction of 0–0, 1–1, and 2–2 domains in the entire data set (1269 domains). SomeP-values were not determined (n.d.) due to the low sample size. (Obs.) Observed; (Exp.) expected.

This Article

  1. Genome Res. 12: 1642-1650

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