Table 4.
Common Symmetrical Domain Families in the Human Genome
| Domain family | Pfam id | No. | Comb. | Frequ. |
| Sushi domain/SCR repeat/CCP module | PF00084 | 144 | 1–1 | 0.98 |
| CUB domain | PF00431 | 65 | 1–1 | 0.95 |
| Laminin-type EGF-like (LE) domain | PF00053 | 34 | 1–1 | 0.82 |
| von Willebrand factor type A domain | PF00092 | 30 | 1–1 | 0.83 |
| Myosin head (motor domain) | PF00063 | 28 | 0–0 | 0.79 |
| EGF-like domain | PF00008 | 22 | 1–1 | 0.82 |
| Discoidin domain/Coagulation factor 5/8 type C domain (FA58C) | PF00754 | 18 | 1–1 | 1.00 |
| Kringle | PF00051 | 18 | 1–1 | 1.00 |
| Crystallin | PF00030 | 16 | 0–0 | 1.00 |
| von Willebrand factor, type C repeat | PF00093 | 16 | 1–1 | 0.94 |
| Major histocompatibility complex protein, Class I | PF00129 | 16 | 1–1 | 0.81 |
| PAN domain | PF00024 | 13 | 1–1 | 0.85 |
| Low density lipoprotein-receptor class A (LDLRA) domain | PF00057 | 13 | 1–1 | 0.92 |
| MHC Class II, alpha chain, alpha-1 domain | PF00993 | 12 | 1–1 | 1.00 |
| MAM domain | PF00629 | 11 | 1–1 | 0.91 |
| IPT/TIG domain | PF01833 | 9 | 1–1 | 1.00 |
| PHD-finger | PF00628 | 8 | 0–0 | 0.75 |
| SEA domain | PF01390 | 8 | 1–1 | 1.00 |
| Link domain | PF00193 | 8 | 1–1 | 1.00 |
| Thrombospondin type I domain | PF00090 | 7 | 1–1 | 0.71 |
| Pancreatic trypsin inhibitor (Kunitz) | PF00014 | 7 | 1–1 | 1.00 |
| Band 4.1 family | PF00373 | 7 | 0–0 | 0.71 |
| GPS domain | PF01825 | 5 | 0–0 | 1.00 |
| TRAF-type zinc finger | PF02176 | 5 | 0–0 | 0.80 |
| Thyroglobulin type-1 repeat | PF00086 | 5 | 1–1 | 1.00 |
| PKD domain | PF00801 | 4 | 1–1 | 1.00 |
| WAP-type (Whey Acidic Protein) four-disulfide core domain | PF00095 | 4 | 1–1 | 1.00 |
| Triple function domain (TRIO) | PF00650 | 4 | 0–0 | 1.00 |
| PX (Bem1/NCF1/PI3K) domain | PF00787 | 4 | 0–0 | 1.00 |
| HYR domain | PF02494 | 4 | 1–1 | 1.00 |
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↵Class 1 and class 2 domains are combined in this overview. Only domain families that occur more than four times in the dataset and for which the symmetrical intron phase combination has a frequency >.7 are shown.
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↵Pfam database identification (http://www.sanger.ac.uk/software/Pfam/index.shtml).
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↵Total number of occurrences.
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↵Flanking intron phase combination.
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↵Frequency of intron phase combination among members of respective domain family.
