Signatures of Domain Shuffling in the Human Genome

Table 3.

Observed and Expected Numbers of Symmetrical Class 1 Domains and Domain Families in Humans

Comb. Obs. Exp. P
Domains (345) 0–0 29 5.3 <10−10
1–1 257 226.2 <10−3
2–2 2 1.4 n.d.
Formula 288 233 <10−7
Domain family (56) 0–0 8.5 5.2 0.13
1–1 24.3 17.9 0.07
2–2 0.2 0.8 n.d.
Formula 33 23.8 <0.05
  • The total number of class 1 domains and families are indicated in parentheses. Summed symmetrical combinations are shown in boldface. The expected values were calculated based on the frequencies of flanking intron phases. Some P-values were not determined (n.d.) due to the low sample size.

  • combination of flanking intron phases.

  • Observed.

  • Expected.

This Article

  1. Genome Res. 12: 1642-1650

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