Using Text Analysis to Identify Functionally Coherent Gene Groups

Table 3.

Assigning Neighbor Divergence Scores to Experimentally Obtained Gene Expression Clusters

Functional label assigned to expression cluster Number of genes Neighbor divergence score Score percentile
ATP synthesis 14 0.1358 99.9%
Chromatin structure 8 0.1456 100.0%
DNA replication 5 0.1867 100.0%
Glycolysis 17 0.2118 100.0%
Mitochondrial ribosome 22 0.0269 53.3%
mRNA splicing 14 0.0248 48.3%
Proteasome 27 0.3007 100.0%
Ribosome and translation 125 0.2224 100.0%
Spindle pole body assembly and function 11 0.0272 53.8%
Tricarboxylic acid cycle and respiration 16 0.1249 99.8%

  • ↵ Eisen et al. (1998) clustered genes from diverse experimental conditions. They labeled 10 of the clusters in Fig. 2 of their paper as containing genes that represent some consistent biological function. Each row represents a gene cluster.

  • ↵Relative to 1900 random gene groups.

This Article

  1. Genome Res. 12: 1582-1590

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