Factors Influencing the Identification of Transcription Factor Binding Sites by Cross-Species Comparison

Table 3.

Phylogenetic Footprinting Results for Selected Species Combinations

Species Number of orthologous data sets Motif predictions with all species included Correspondence with known sites
EC-ST 161 98.8% (159/161) 55.3% (88/159)
EC-YP 138 94.2% (130/138) 66.9% (87/130)
EC-VC 112 83.0% (93/112) 62.4% (58/93)
EC-HI 72 81.9% (59/72) 62.7% (37/59)
EC-SO 91 69.2% (63/91) 55.6% (35/63)
EC-PA 92 48.9% (45/92) 37.8% (17/45)
EC-BU 27 85.2% (23/27) 39.1% (9/23)
EC-AF 46 58.7% (27/46) 48.1% (13/27)
EC-XF 50 54.0% (27/50) 33.3% (9/27)
EC-VC-HI 65 50.8% (33/65) 75.8% (25/33)
EC-YP-SO 86 36.0% (31/86) 67.7% (21/31)
EC-YP-PA 86 19.8% (17/86) 70.6% (12/17)
EC-ST-YP-VC 103 42.7% (44/103) 86.4% (38/44)
  • Results for all species combinations are in the Supplementary Data.

  • Species abbreviations are as follows: EC,Escherichia coli; ST, Salmonella typhi; YP,Yersinia pestis; VC, Vibrio cholerae; HI,Haemophilus influenzae; SO, Shewanella oneidensis; PA, Pseudomonas aeruginosa; BU,Buchnera sp.; AF, Acidithiobacillus ferrooxidans;and XF, Xylella fastidiosa.

  • Correspondence with known E. coli transcription factor binding sites was calculated only for those motif predictions that contained sites from all the species included in the data set.

This Article

  1. Genome Res. 12: 1523-1532

Preprint Server