Identification of the Single Base Change Causing the Callipyge Muscle Hypertrophy Phenotype, the Only Known Example of Polar Overdominance in Mammals

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Figure 2.
Figure 2.

Ram 198812900 exhibits an inbreeding path with the sire (S318167) of Solid Gold contributing on both maternal and paternal sides of the pedigree. We hypothesized that this inbreeding path has allowed the region to be identical-by-descent, except for the CLPGmutation, which we propose occurred in the gamete that produced Solid Gold. The C identifies the mutated allele, and individuals with the muscle hypertrophy phenotype are identified as solid black sheep; those with normal phenotype are identified as gray sheep. Wild-type chromosomes are represented as gray chromatids. A recombination event is depicted to have occurred on the maternal side of the pedigree; however, the event could have occurred on either or both sides to generate marker informativeness in the centromeric region of chromosome 18.

This Article

  1. Genome Res. 12: 1496-1506

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