Human Paralogs of KIAA0187 Were Created through Independent Pericentromeric-Directed and Chromosome-Specific Duplication Mechanisms

Table 2.

Pairwise Distances Betweeen KIAA0187paralog

A. KIAA0187—Distal paralog (1892 bp)
1 2 3 4 5 6 7 8 % sim. to KIAA0187 Alignment length (bp)
AC068279 — 95.42 6300
AC026273 0.022 — 95.95 18061
AC024573 0.012 0.019 — 95.48 6308
D87003/18 0.020 0.019 0.016 — 96.02 16610
AC036220 0.026 0.025 0.023 0.022 — 95.90 26239
AC010098 0.015 0.021 0.013 0.019 0.025 — 94.98 10801
AC018696 0.007 0.023 0.011 0.021 0.028 0.015 — — 95.30 11140
AC013411 0.026 0.032 0.024 0.030 0.036 0.018 0.026 94.43 3609
KIAA0187 0.042 0.041 0.040 0.038 0.043 0.040 0.041 0.052 — —
B. KIAA0187—Proximal paralog (1909 bp)
1 2 3 4 % sim. to KIAA0187 Alignment length (bp)
AL136982 — 92.80 18254
AL135925 0.058 — 91.19  5787
AC022400 0.063 0.055 — 92.54 14876
AL391137 0.069 0.059 0.058 — 92.81  9930
KIAA0187 0.077 0.070 0.073 0.082 —

  • Kimura 2 parameter distances between the functionalKIAA0187 gene and 11 paralogs are shown, calculated over the sequence ranges employed in the phylogenetic analyses (Fig. 4). The % similarity of each paralog to KIAA0187 is also shown. These are calculated over the full alignment length with the exception ofAC013411 where unfinished sequence prevents a complete alignment. The % similarity shared between KIAA0187 and the paralogs with a physical structure that precluded inclusion in the multiple alignments (with alignment lengths) are as follows: AL450334, 92.68% (4451 bp); AC018963, 95.42% (14891 bp); AC016424, 95.60% (12106 bp); and AP000525/6, 91.25% (31819 bp).

This Article

  1. Genome Res. 12: 67-80

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