Human Paralogs of KIAA0187 Were Created through Independent Pericentromeric-Directed and Chromosome-Specific Duplication Mechanisms

Table 1.

Sequence Features Within Clones Containing KIAA0187Paralog

Clone (accession no.) Paralog classification Long tandem repeats in clones % Tandem repeats Known genes in clone(s) Draft map position FISH mapping
AC026273 distal Alpha Sat, CATTT,  CAGGG 31.4 Not placed 1cen, 2cen, 9p12,  9q12, 13cen,  16cen, 22cen
AC068279 distal GCTG, AluSx,  CATTT, CAGGG 21.2 2q13 1qcen, 2cen, 2q13,  9cen, 15q11,  16p11
AC018696 distal AluSx,CAGC, Sat II,  CATTT, CAGGG 18.4 2p13 n.d.
AC024573 distal CATTT, CAGGG,  CAGC, AluSx 13.2 2p11 n.d.
AC016424 distal CAGGG, CATTT,  Alpha Sat 12.9 2p11 1cen,2cen, 7cen,  9p12, 9q12,  13nor, 14cen,  16p11, 22q11+nor  cen
AC010098 distal CAGC, CATATT, AT  complex,CAGGG 10.7 2p11 1cen, 2cen,16cen
D87003/18 distal CAGGG, CATTT 9.7 22q11 n.d.
AC013411 distal CAGGG, CATTT 6.2 1 unplaced 1cen, 2cen, 13cen,  15cen, 16cen
AC018963 distal AluSx, CATTT,  CAGGG 4.7 15q11.2 1q11, 2cen, 9p12,  9q12, 16q11,  15q11
AC036220 distal CAGGG, CATTT 3.8 16p12.3 1cen, 2cen, 14cen,  16cen
AP000525/6 distal/proximal 0.8 22q11 n.d.
AL450334 proximal 0.0 Not present 10q11,10q23
AL391137 proximal 1.97 Annexin A8  (Chr10:  69–72cM) 10q11.2 2q23, 6q11, 8pter,  8q23,10q11,  12q22, 16pter
AC022400 proximal 0.44 Heparan  N-deacetylase  (97–98cM) 10q22.2 10q11,10q22
AL135925 proximal 1.17 Lung surfactant  protein D  Chr10:  98–107cM) 10q22.3 10q11,10q23.1
AL136982 proximal 0.57 GLUDI (Chr10:  114–199cM) 10q23.2 10q11, 10q23.3
  • Paralog classification is based on exons present (see text for details). AluSx refers to a tandem array of up to 43Alu elements, mostly of the AluSg/x subfamily. The only tandem repeats in the proximal clones are di-, tri-, and tetranucleotide repeats. Genetic intervals defining gene positions were taken from Deloukas et al. (1998). Current map positions for each clone are derived from the UCSC sequence (December 2000 build, http://genome.ucsc.edu/ ).

This Article

  1. Genome Res. 12: 67-80

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