Domain architecture of proteins containing the RWD domain. Only proteins with distinct modular organizations are shown. The domain names are according to the Simple Modular Architecture Research Tool (http://smart.embl-heidelberg.de) (Schultz et al. 1998,2000). DEAD (DEXDc)-like helicases superfamily (N-terminal domain); HELICc, helicase superfamily (C-terminal domain); RING, RING finger domain; STYKc, protein kinases (unclassified specificity); UBA, ubiquitin-associated domain; WD40, WD40 repeats. The RING finger domain in the dashed box is not recognized by SMART or Pfam. The STYKc domain in the dashed box is degenerated (partial and noncatalytic). The IBR (In between Ring fingers) domain and UPF29 (uncharacterized protein family) are defined by Pfam (Bateman et al. 2000). The HisRS (histidyl-tRNA synthetase) domain is defined by literature (Sattleger et al. 1998).
