The KA/KS Ratio Test for Assessing the Protein-Coding Potential of Genomic Regions: An Empirical and Simulation Study

Table 1.

Descriptive Statistics of Human Protein-Coding Exons

Exons No. of exons Length GC% % Identity with mouse
range mean median overall third pos.
All 1219 30–1842 147 123 52.1 ± 9.6 59.4 ± 19.3 86.5 ± 8.0
Initial 114 30–1842 222 190 59.6 ± 10.2 72.7 ± 17.0
Internal 991 30–624 132 123 51.0 ± 9.1 57.5 ± 19.1
Terminal 114 30–1167 203 190 54.5 ± 10.2 63.9 ± 18.7
Single-exon genes 25 327–4737 1376 1228 56.1 ± 9.6 68.2 ± 19.0
  • Comparisons of human and mouse sequences often involve insertion/deletion events. Therefore, the alignable length of exons in this study is sometimes smaller than their actual length. However, in the majority of cases (1104 of 1244, or 88%) alignable length is equal to the actual lengths of human and mouse sequences.

  • Minimal alignable length was set to 30 bp.

  • Excluding single-exon genes.

  • Only coding parts of the initial and terminal exons were included.

This Article

  1. Genome Res. 12: 198-202

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