cis Element/Transcription Factor Analysis (cis/TF): A Method for Discovering Transcription Factor/cis Element Relationships

Table 1.

cis/TF's Matches to Documented TF Binding Sites

TF Rank Correlation (rvalue) Significance level Program prediction Documented site
Knockout lines
STE12 4 0.89 0.001 ?TGAAAC ATGAAA
BAS1 7 0.52 0.01 ?GAGTCA GAGTCA
PDR3 5 0.65 0.05 CGCGG?T TCCG(C,T)GGA
MET28 4 0.87 0.001 ?GTCACG TCACGTG
GCR1 2 0.99 0.001 ACCA?CC C(A,T)TCC
GCN4 38 0.50 0.01 TGACTC? TGANTN
Total evaluated: 11
Cell cycle (high density arrays)
MET32 2 0.99 0.001 CT?TGGC AACTGTGG
GCN4 2 0.95 0.001 CTGAC?C TGANTN
Total evaluated: 6
Cell cycle (cDNA arrays)
PHO4 1 0.95 0.002 CACG?G CACGT(T,G)
Total evaluated: 9
  • Probability that the correlation is different from zero.

  • Taken from SCPD.

  • “?” denotes a position where the program allowed any base.

  • These two did not meet criteria for successful hits.

  • Approximately one-half of the 20 documented GCN4 binding sites in SCPD contained the sequence TGACTC.

This Article

  1. Genome Res. 11: 1567-1573

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