A Predictive Model for Regulatory Sequences Directing Liver-Specific Transcription

Table 2.

Putative Liver Modules

gene LMM score BLAST E -value Human Rodent
human rodent acc. # begin/end species acc. # begin/end
(a) CYP7A1 0.59 0.35 5.1 × 10−14 L04629 278/577 cg L04690 1303/1602
G6PC 0.97 0.63 2.4 × 10−16 AF051355 3530/3829 mm U91573 293/592
G6PC 0.97 0.33 1.1 × 10−18 AF051355 3506/3805 rn U57552 1180/1479
IGF1 0.30 0.39 1.3 × 10−14 M12659 1266/1565 mm Y18062 1223/1522
PAH 0.30 0.90 2.0 × 10−20 AF033857 1293/1592 mm X97253 726/1025
(b) FGA 0.28 0.37 5.0 × 10−14 U36478 12780/13079 rn X86561 1480/1779
HNF1 0.31 0.31 4.5 × 10−70 U73499 294/593 rr X63959 14/313
HNF1 0.31 0.31 8.4 × 10−65 U73499 294/593 rn X67649 3282/3581
IGFBP1 0.41 0.45 4.3 × 10−18 M23592 64/363 mm X67493 493/792
MTP 0.50 0.62 5.2 × 10−35 S71339 509/808 cg S74104 0/299
(c) MIG6 0.49 0.50 2.0 × 10−20 AL034417 76528/76827 rr X07267 0/299
BF 0.75 0.56 9.3 × 10−23 AF019413 79680/79979 mm AF109906 10767/11066
(d) FABP2 0.29 0.58 4.3 × 10−18 M18079 588/887 mm M65033 285/584
GUCA2B 0.40 0.49 2.4 × 10−16 Z70295 768/1067 mm AF006668 362/661
HOXA4 0.48 0.48 6.4 × 10−96 U41755 814/1113 mm U75897 734/1033
SLC34A1 0.27 0.39 2.0 × 10−20 AF058289 1629/1928 mm AF071876 3978/4277

  • Abbreviations: cg, Cricetulus griseus; mm, Mus musculus; rn, Rattus norvegicus; rr, Rattus rattus.

This Article

  1. Published in Advance August 16, 2001, doi: 10.1101/gr.180601 Genome Res. 11: 1559-1566

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